The House of the Dead 2 occurs two years later, with a citywide incident organized by Caleb Goldman, the head of a financial group and the mastermind of the mansion incident. Curien, a genetic engineer who went insane and has released creatures upon his own research team.
The House of the Dead and its 2021 remake take place in 1998, following AMS agents Thomas Rogan and G as they raid the mansion of Dr. The main House of the Dead series follows worldwide incidents involving hostile biologically-engineered lifeforms, referred to as creatures, and the government agency AMS' efforts to neutralize them.